EPHB6

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EPH receptor B6
Identifikatori
SimboliEPHB6; HEP
Vanjski IDOMIM: 602757 MGI: 1096338 HomoloGene: 20940 GeneCards: EPHB6 Gene
EC broj2.7.10.1
Ontologija gena
Molekulska funkcija • receptorska aktivnost
• efrinska receptorska aktivnost
• ATP vezivanje
Ćelijska komponenta • extracelularni region
• integralna komponenta ćelijske membrane
Biološki proces • proteinska fosforilacija
• paratiroid hormonska sekrecija
• signalni put efrinskog receptora
Pregled RNK izražavanja
podaci
Ortolozi
VrstaČovekMiš
Entrez205113848
EnsemblENSG00000106123ENSMUSG00000029869
UniProtO15197O08644
Ref. Sekv. (iRNK)NM_001280794NM_001146351
Ref. Sekv. (protein)NP_001267723NP_001139823
Lokacija (UCSC)Chr 7:
142.55 - 142.57 Mb		Chr 6:
41.61 - 41.62 Mb
PubMed pretraga[1][2]

Receptor 6 efrinskog tipa B je protein koji je kod ljudi kodiran EPHB6 genom.[1]

Efrinski receptori i njihovi ligandi, efrini, posreduju brojne procese razvića, posebno u nervnom sistemu. Na bazi njihovih struktura i sekvenci, efrini se dele u efrinsku klasu A (EFNA), koja se fiksira na membrani putem glikozilfosfatidilinozitolne veze, i efrinsku klasu B (EFNB), koji su transmembranski proteini. Eph familija receptora se deli u dve groupe na osnovu sličnosti njihovih sekvenci ekstracelularnog domena i njihovog afiniteta vezivanja liganda efrina A i efrina B. Efrinski receptori su najveća podgrupa receptora tirozinske kinazne (RTK) familije. Protein kodiran ovim genom je receptor za efrinske-B članove familije.[1]

Reference

  1. ↑ 1,0 1,1 „Entrez Gene: EPHB6 EPH receptor B6”. 

Literatura

  • Flanagan JG, Vanderhaeghen P (1998). „The ephrins and Eph receptors in neural development”. Annu. Rev. Neurosci. 21: 309–45. DOI:10.1146/annurev.neuro.21.1.309. PMID 9530499. 
  • Zhou R (1998). „The Eph family receptors and ligands”. Pharmacol. Ther. 77 (3): 151–81. DOI:10.1016/S0163-7258(97)00112-5. PMID 9576626. 
  • Holder N, Klein R (1999). „Eph receptors and ephrins: effectors of morphogenesis”. Development 126 (10): 2033–44. PMID 10207129. 
  • Wilkinson DG (2000). „Eph receptors and ephrins: regulators of guidance and assembly”. Int. Rev. Cytol.. International Review of Cytology 196: 177–244. DOI:10.1016/S0074-7696(00)96005-4. ISBN 978-0-12-364600-2. PMID 10730216. 
  • Xu Q, Mellitzer G, Wilkinson DG (2001). „Roles of Eph receptors and ephrins in segmental patterning”. Philos. Trans. R. Soc. Lond., B, Biol. Sci. 355 (1399): 993–1002. DOI:10.1098/rstb.2000.0635. PMC 1692797. PMID 11128993. 
  • Wilkinson DG (2001). „Multiple roles of EPH receptors and ephrins in neural development”. Nat. Rev. Neurosci. 2 (3): 155–64. DOI:10.1038/35058515. PMID 11256076. 
  • Bonaldo MF, Lennon G, Soares MB (1997). „Normalization and subtraction: two approaches to facilitate gene discovery”. Genome Res. 6 (9): 791–806. DOI:10.1101/gr.6.9.791. PMID 8889548. 
  • Matsuoka H, Iwata N, Ito M, et al. (1997). „Expression of a kinase-defective Eph-like receptor in the normal human brain”. Biochem. Biophys. Res. Commun. 235 (3): 487–92. DOI:10.1006/bbrc.1997.6812. PMID 9207182. 
  • Ephnomenclaturecommittee, (1997). „Unified nomenclature for Eph family receptors and their ligands, the ephrins. Eph Nomenclature Committee”. Cell 90 (3): 403–4. DOI:10.1016/S0092-8674(00)80500-0. PMID 9267020. 
  • Hock B, Böhme B, Karn T, et al. (1998). „PDZ-domain-mediated interaction of the Eph-related receptor tyrosine kinase EphB3 and the ras-binding protein AF6 depends on the kinase activity of the receptor”. Proc. Natl. Acad. Sci. U.S.A. 95 (17): 9779–84. DOI:10.1073/pnas.95.17.9779. PMC 21413. PMID 9707552. 
  • Munthe E, Rian E, Holien T, et al. (2000). „Ephrin-B2 is a candidate ligand for the Eph receptor, EphB6”. FEBS Lett. 466 (1): 169–74. DOI:10.1016/S0014-5793(99)01793-7. PMID 10648835. 
  • Shimoyama M, Matsuoka H, Tamekane A, et al. (2000). „T-cell-specific expression of kinase-defective Eph-family receptor protein, EphB6 in normal as well as transformed hematopoietic cells”. Growth Factors 18 (1): 63–78. DOI:10.3109/08977190009003234. PMID 10831073. 
  • Tang XX, Zhao H, Robinson ME, et al. (2000). „Implications of EPHB6, EFNB2, and EFNB3 expressions in human neuroblastoma”. Proc. Natl. Acad. Sci. U.S.A. 97 (20): 10936–41. DOI:10.1073/pnas.190123297. PMC 27127. PMID 10984508. 
  • Luo H, Wan X, Wu Y, Wu J (2001). „Cross-linking of EphB6 resulting in signal transduction and apoptosis in Jurkat cells”. J. Immunol. 167 (3): 1362–70. DOI:10.4049/jimmunol.167.3.1362. PMID 11466354. 
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Receptori faktora rasta
EGFR • ERBB2 • ERBB3 • ERBB4
IGF1R • INSR • INSRR
CSF1R • FLT3 • KIT • PDGFR (PDGFRA, PDGFRB)
FGFR1 • FGFR2 • FGFR3 • FGFR4
VEGFR1 • VEGFR2 • VEGFR3 • VEGFR4
MET • RON
NTRK1 • NTRK2 • NTRK3
EPH receptorska familija
EPHA1 • EPHA2 • EPHA3 • EPHA4 • EPHA5 • EPHA6 • EPHA7 • EPHA8 • EPHB1 • EPHB2 • EPHB3 • EPHB4 • EPHB5 • EPHB6 • EPHX
LTK receptorska familija
LTK • ALK
TIE receptorska familija
TIE • TEK
ROR receptorska familija
ROR1 • ROR2
DDR receptorska familija
DDR1 • DDR2
PTK7 receptorska familija
RYK receptorska familija
MuSK receptorska familija
ROS receptorska familija
ROS1
AATYK receptorska familija
AATYK • AATYK2 • AATYK3
AXL receptorska familija
AXL • MER • TYRO3
RET receptorska familija
nekategorisani
  • p
  • r
  • u
ABL familija
ABL1 • ARG
ACK familija
ACK1 • TNK1
CSK familija
CSK • MATK
FAK familija
FAK • PYK2
FES familija
FES • FER
FRK familija
FRK • BRK • SRMS
JAK familija
JAK1 • JAK2 • JAK3 • TYK2
SRC-A familija
SRC • FGR • FYN • YES1
SRC-B familija
BLK • HCK • LCK • LYN
TEC familija
TEC • BMX • BTK • ITK • TXK
SYK familija
SYK • ZAP70
B enzm: 1.1/2/3/4/5/6/7/8/10/11/13/14/15-18, 2.1/2/3/4/5/6/7/8, 2.7.10, 2.7.11-12, 3.1/2/3/4/5/6/7, 3.1.3.48, 3.4.21/22/23/24, 4.1/2/3/4/5/6, 5.1/2/3/4/99, 6.1-3/4/5-6