EPHA8
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| EPH receptor A8 | |||||||||||
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 PDB baziran na 1ucv. | |||||||||||
| Dostupne strukture | |||||||||||
| 1UCV, 1X5L, 3KUL | |||||||||||
| Identifikatori | |||||||||||
| Simboli | EPHA8; EEK; EK3; HEK3 | ||||||||||
| Vanjski ID | OMIM: 176945 MGI: 109378 HomoloGene: 22436 GeneCards: EPHA8 Gene | ||||||||||
| EC broj | 2.7.10.1 | ||||||||||
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| Ortolozi | |||||||||||
| Vrsta | Čovek | Miš | |||||||||
| Entrez | 2046 | 13842 | |||||||||
| Ensembl | ENSG00000070886 | ENSMUSG00000028661 | |||||||||
| UniProt | P29322 | O09127 | |||||||||
| Ref. Sekv. (iRNK) | NM_001006943 | NM_007939 | |||||||||
| Ref. Sekv. (protein) | NP_001006944 | NP_031965 | |||||||||
| Lokacija (UCSC) | Chr 1: 22.89 - 22.93 Mb | Chr 4: 136.93 - 136.96 Mb | |||||||||
| PubMed pretraga | [1] | [2] | |||||||||
Receptor 8 efrinskog tipa A je protein koji je kod ljudi kodiran EPHA8 genom.[1][2]
Ovaj gen kodira člana efrinske receptorske podfamilije proteinskih tirozinskih kinaza. EPH i EPH-srodni receptori učestvuju u posredovanja događaja razvića, posebno u nervnom sistemu. Receptori EPH podfamilije tipično imaju jedan kinazni domen, ekstracelularni region koji sadrži domen bogat cisteinom i dva ponavljanja fibronektinskog tipa III. Efrinski receptori se dele u dve grupe na bazi sličnosti sekvenci njihovih ekstracelularnih domena i njihovih afiniteta vezivanja liganda efrina A i efrina B. Protein kodiran ovim genom funkcioniše kao receptor za efrin A2, A3 i A5, i učestvuje u posredovanju bliskih kontakta pri aksonskom navođenju tokom razvića nervnog sistema sisara.[2]
Interakcije
EPHA8 formira interakcije sa FYN.[3]
Reference
- ↑ Chan J, Watt VM (Aug 1991). „eek and erk, new members of the eph subclass of receptor protein-tyrosine kinases”. Oncogene 6 (6): 1057–61. PMID 1648701.
- ↑ 2,0 2,1 „Entrez Gene: EPHA8 EPH receptor A8”.
- ↑ Choi, S; Park S (Sep 1999). „Phosphorylation at Tyr-838 in the kinase domain of EphA8 modulates Fyn binding to the Tyr-615 site by enhancing tyrosine kinase activity”. Oncogene (ENGLAND) 18 (39): 5413–22. DOI:10.1038/sj.onc.1202917. ISSN 0950-9232. PMID 10498895.
Literatura
- Flanagan JG, Vanderhaeghen P (1998). „The ephrins and Eph receptors in neural development.”. Annu. Rev. Neurosci. 21: 309–45. DOI:10.1146/annurev.neuro.21.1.309. PMID 9530499.
- Holland SJ, Peles E, Pawson T, Schlessinger J (1998). „Cell-contact-dependent signalling in axon growth and guidance: Eph receptor tyrosine kinases and receptor protein tyrosine phosphatase beta.”. Curr. Opin. Neurobiol. 8 (1): 117–27. DOI:10.1016/S0959-4388(98)80015-9. PMID 9568399.
- Zhou R (1998). „The Eph family receptors and ligands.”. Pharmacol. Ther. 77 (3): 151–81. DOI:10.1016/S0163-7258(97)00112-5. PMID 9576626.
- Holder N, Klein R (1999). „Eph receptors and ephrins: effectors of morphogenesis.”. Development 126 (10): 2033–44. PMID 10207129.
- Wilkinson DG (2000). „Eph receptors and ephrins: regulators of guidance and assembly.”. Int. Rev. Cytol. 196: 177–244. DOI:10.1016/S0074-7696(00)96005-4. PMID 10730216.
- Xu Q, Mellitzer G, Wilkinson DG (2001). „Roles of Eph receptors and ephrins in segmental patterning.”. Philos. Trans. R. Soc. Lond., B, Biol. Sci. 355 (1399): 993–1002. DOI:10.1098/rstb.2000.0635. PMC 1692797. PMID 11128993.
- Wilkinson DG (2001). „Multiple roles of EPH receptors and ephrins in neural development.”. Nat. Rev. Neurosci. 2 (3): 155–64. DOI:10.1038/35058515. PMID 11256076.
- Nakamoto T, Kain KH, Ginsberg MH (2004). „Neurobiology: New connections between integrins and axon guidance.”. Curr. Biol. 14 (3): R121–3. DOI:10.1016/j.cub.2004.01.020. PMID 14986683.
- Yamaguchi Y, Pasquale EB (2004). „Eph receptors in the adult brain.”. Curr. Opin. Neurobiol. 14 (3): 288–96. DOI:10.1016/j.conb.2004.04.003. PMID 15194108.
- Murai KK, Pasquale EB (2004). „Eph receptors, ephrins, and synaptic function.”. The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry 10 (4): 304–14. DOI:10.1177/1073858403262221. PMID 15271258.
- Park S, Sánchez MP (1997). „The Eek receptor, a member of the Eph family of tyrosine protein kinases, can be activated by three different Eph family ligands.”. Oncogene 14 (5): 533–42. DOI:10.1038/sj.onc.1200857. PMID 9053851.
- Park S, Frisén J, Barbacid M (1997). „Aberrant axonal projections in mice lacking EphA8 (Eek) tyrosine protein kinase receptors.”. EMBO J. 16 (11): 3106–14. DOI:10.1093/emboj/16.11.3106. PMC 1169929. PMID 9214628.
- Ephnomenclaturecommittee, (1997). „Unified nomenclature for Eph family receptors and their ligands, the ephrins. Eph Nomenclature Committee.”. Cell 90 (3): 403–4. DOI:10.1016/S0092-8674(00)80500-0. PMID 9267020.
- Lemke G (1998). „A coherent nomenclature for Eph receptors and their ligands.”. Mol. Cell. Neurosci. 9 (5–6): 331–2. DOI:10.1006/mcne.1997.0630. PMID 9361271.
- Choi S, Park S (1999). „Phosphorylation at Tyr-838 in the kinase domain of EphA8 modulates Fyn binding to the Tyr-615 site by enhancing tyrosine kinase activity.”. Oncogene 18 (39): 5413–22. DOI:10.1038/sj.onc.1202917. PMID 10498895.
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