CEP70

Protein-coding gene in the species Homo sapiens
CEP70
Identifiers
AliasesCEP70, BITE, centrosomal protein 70
External IDsOMIM: 614310; MGI: 1915371; HomoloGene: 11387; GeneCards: CEP70; OMA:CEP70 - orthologs
Gene location (Human)
Chromosome 3 (human)
Chr.Chromosome 3 (human)[1]
Chromosome 3 (human)
Genomic location for CEP70
Genomic location for CEP70
Band3q22.3Start138,494,344 bp[1]
End138,594,538 bp[1]
Gene location (Mouse)
Chromosome 9 (mouse)
Chr.Chromosome 9 (mouse)[2]
Chromosome 9 (mouse)
Genomic location for CEP70
Genomic location for CEP70
Band9|9 E3.3Start99,243,367 bp[2]
End99,300,404 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • Achilles tendon

  • sperm

  • right uterine tube

  • ventricular zone

  • left testis

  • right testis

  • ganglionic eminence

  • body of pancreas

  • duodenum

  • jejunal mucosa
Top expressed in
  • zygote

  • secondary oocyte

  • spermatocyte

  • genital tubercle

  • primary oocyte

  • trigeminal ganglion

  • substantia nigra

  • saccule

  • ventricular zone

  • ganglionic eminence
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • protein binding
  • identical protein binding
  • gamma-tubulin binding
Cellular component
  • microtubule organizing center
  • cytoskeleton
  • cytoplasm
  • nucleoplasm
  • cytosol
  • nuclear membrane
  • centrosome
Biological process
  • G2/M transition of mitotic cell cycle
  • ciliary basal body-plasma membrane docking
  • regulation of G2/M transition of mitotic cell cycle
  • cilium assembly
  • regulation of microtubule cytoskeleton organization
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

80321

68121

Ensembl

ENSG00000114107

ENSMUSG00000056267

UniProt

Q8NHQ1

Q6IQY5

RefSeq (mRNA)
NM_001288964
NM_001288965
NM_001288966
NM_001288967
NM_024491

NM_001320598
NM_001320599
NM_001320600

NM_023873

RefSeq (protein)
NP_001275893
NP_001275894
NP_001275895
NP_001275896
NP_001307527

NP_001307528
NP_001307529
NP_077817

NP_076362

Location (UCSC)Chr 3: 138.49 – 138.59 MbChr 9: 99.24 – 99.3 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Centrosomal protein of 70 kDa is a protein that in humans is encoded by the CEP70 gene.[5][6] The protein interacts with γ-tubulin through its coiled coil domains to localize at the centrosome. CEP70 is involved in organizing microtubules in interphase cells and is required for proper organization and orientation of the mitotic spindle.[7]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000114107 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000056267 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Andersen JS, Wilkinson CJ, Mayor T, Mortensen P, Nigg EA, Mann M (Dec 2003). "Proteomic characterization of the human centrosome by protein correlation profiling". Nature. 426 (6966): 570–4. Bibcode:2003Natur.426..570A. doi:10.1038/nature02166. PMID 14654843. S2CID 4427303.
  6. ^ "Entrez Gene: CEP70 centrosomal protein 70kDa".
  7. ^ Shi X, Sun X, Liu M, Li D, Aneja R, Zhou J (September 2011). "CEP70 protein interacts with γ-tubulin to localize at the centrosome and is critical for mitotic spindle assembly". J. Biol. Chem. 286 (38): 33401–8. doi:10.1074/jbc.M111.252262. PMC 3190865. PMID 21795687.

External links

Further reading

  • Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569. S2CID 13709685.
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.


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