CEP68

Protein-coding gene in the species Homo sapiens

CEP68

Identifiers

Aliases

CEP68, KIAA0582, centrosomal protein 68

External IDs

OMIM: 616889; MGI: 2667663; HomoloGene: 65235; GeneCards: CEP68; OMA:CEP68 - orthologs

Gene location (Human)

Chr.	Chromosome 2 (human)^[1]

Band	2p14	Start	65,056,366 bp^[1]
Band	2p14	End	65,087,004 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 11 (mouse)^[2]

Band	11 A3.1\|11 12.92 cM	Start	20,177,037 bp^[2]
Band	11 A3.1\|11 12.92 cM	End	20,199,429 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

biceps brachii

Skeletal muscle tissue of biceps brachii

glutes

Skeletal muscle tissue of rectus abdominis

skin of hip

skin of thigh

superficial temporal artery

parietal pleura

urethra

nipple

Top expressed in

Rostral migratory stream

digastric muscle

extraocular muscle

sternocleidomastoid muscle

triceps brachii muscle

soleus muscle

temporal muscle

abdominal wall

vastus lateralis muscle

myocardium of ventricle

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	protein domain specific binding protein kinase binding protein binding
Cellular component	cell junction nucleus centrosome microtubule organizing center cytoskeleton cytoplasm cytosol
Biological process	protein localization to organelle centriole-centriole cohesion centrosome cycle
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


23177


216543

Ensembl


ENSG00000011523


ENSMUSG00000044066

UniProt


Q76N32


Q8C0D9

RefSeq (mRNA)


NM_015147 NM_001319100 NM_001319101


NM_172260

RefSeq (protein)


NP_001306029 NP_001306030 NP_055962


NP_758464

Location (UCSC)

Chr 2: 65.06 – 65.09 Mb

Chr 11: 20.18 – 20.2 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Centrosomal protein of 68 kDa is a protein that in humans is encoded by the CEP68 gene.^[5]^[6]^[7]^[8] CEP68 is required for centrosome cohesion. It decorates fibres emanating from the proximal ends of centrioles. During mitosis, CEP68 dissociates from centrosomes. CEP68 and rootletin depend both on each other for centriole association, and both also require CEP250 for their function.^[9]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000011523 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000044066 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Nagase T, Ishikawa K, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Feb 1998). "Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Research. 5 (1): 31–9. doi:10.1093/dnares/5.1.31. PMID 9628581.
^ Sanger Centre, The; Washington University Genome Sequencing Cente, The (Nov 1998). "Toward a complete human genome sequence". Genome Research. 8 (11): 1097–108. doi:10.1101/gr.8.11.1097. PMID 9847074.
^ Andersen JS, Wilkinson CJ, Mayor T, Mortensen P, Nigg EA, Mann M (Dec 2003). "Proteomic characterization of the human centrosome by protein correlation profiling". Nature. 426 (6966): 570–4. Bibcode:2003Natur.426..570A. doi:10.1038/nature02166. PMID 14654843. S2CID 4427303.
^ "Entrez Gene: CEP68 centrosomal protein 68kDa".
^ Graser S, Stierhof YD, Nigg EA (Dec 2007). "Cep68 and Cep215 (Cdk5rap2) are required for centrosome cohesion". Journal of Cell Science. 120 (Pt 24): 4321–31. doi:10.1242/jcs.020248. PMID 18042621. S2CID 7307094.

External links

Human CEP68 genome location and CEP68 gene details page in the UCSC Genome Browser.

Nakajima D, Okazaki N, Yamakawa H, Kikuno R, Ohara O, Nagase T (Jun 2002). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Research. 9 (3): 99–106. doi:10.1093/dnares/9.3.99. PMID 12168954.
Wistow G, Bernstein SL, Wyatt MK, Fariss RN, Behal A, Touchman JW, Bouffard G, Smith D, Peterson K (Jun 2002). "Expressed sequence tag analysis of human RPE/choroid for the NEIBank Project: over 6000 non-redundant transcripts, novel genes and splice variants". Molecular Vision. 8: 205–20. PMID 12107410.
Wang HY, Chien HC, Osada N, Hashimoto K, Sugano S, Gojobori T, Chou CK, Tsai SF, Wu CI, Shen CK (Feb 2007). "Rate of evolution in brain-expressed genes in humans and other primates". PLOS Biology. 5 (2): e13. doi:10.1371/journal.pbio.0050013. PMC 1717015. PMID 17194215.
Chen Y, Low TY, Choong LY, Ray RS, Tan YL, Toy W, Lin Q, Ang BK, Wong CH, Lim S, Li B, Hew CL, Sze NS, Druker BJ, Lim YP (Jul 2007). "Phosphoproteomics identified Endofin, DCBLD2, and KIAA0582 as novel tyrosine phosphorylation targets of EGF signaling and Iressa in human cancer cells". Proteomics. 7 (14): 2384–97. doi:10.1002/pmic.200600968. PMID 17570516. S2CID 23944956.