S1PR1

S1PR1
Struktur yang tersedia PDB Pencarian Ortolog: PDBe RCSB Daftar kode id PDB 3V2W, 3V2Y
Pengidentifikasi
Alias	S1PR1, CD363, CHEDG1, D1S3362, ECGF1, EDG-1, EDG1, S1P1, sphingosine-1-phosphate receptor 1
ID eksternal	OMIM: 601974 MGI: 1096355 HomoloGene: 1071 GeneCards: S1PR1
Lokasi gen (Tikus) Kr. Kromosom 3 (tikus)[1] Pita 3|3 G1 Awal 115,504,082 bp[1] Akhir 115,508,721 bp[1]
Pola ekspresi RNA Referensi data ekspresi selengkapnya
Ontologi gen Fungsi molekuler • sphingolipid binding • sphingosine-1-phosphate receptor activity • G protein-coupled receptor activity • signal transducer activity • G protein-coupled receptor binding • GO:0001948, GO:0016582 Ikatan protein plasma Komponen seluler • komponen integral membran • endosom • membran • intrinsic component of plasma membrane • Membran sel • membrane raft • external side of plasma membrane • nucleoplasm • intracellular membrane-bounded organelle Proses biologis • actin cytoskeleton reorganization • T cell migration • G protein-coupled receptor signaling pathway • heart trabecula morphogenesis • positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • sphingosine-1-phosphate receptor signaling pathway • positive regulation of cell migration • regulation of bone mineralization • transmission of nerve impulse • chemotaxis • positive regulation of positive chemotaxis • GO:0032320, GO:0032321, GO:0032855, GO:0043089, GO:0032854 positive regulation of GTPase activity • brain development • regulation of cell adhesion • Adhesi sel • Angiogenesis • neuron differentiation • positive regulation of cell population proliferation • endothelial cell differentiation • negative regulation of stress fiber assembly • regulation of bone resorption • Migrasi sel • GO:0072468 signal transduction • lamellipodium assembly • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • cardiac muscle tissue growth involved in heart morphogenesis • positive regulation of smooth muscle cell proliferation • blood vessel maturation • leukocyte chemotaxis • cytokine-mediated signaling pathway Sumber:Amigo / QuickGO
Ortolog
Spesies	Manusia	Tikus
Entrez	1901	13609
Ensembl	ENSG00000170989	ENSMUSG00000045092
UniProt	P21453	O08530
RefSeq (mRNA)	NM_001400 NM_001320730	NM_007901
RefSeq (protein)	NP_001307659 NP_001391	NP_031927
Lokasi (UCSC)	n/a	Chr 3: 115.5 – 115.51 Mb
Pencarian PubMed	[2]	[3]
Wikidata
Lihat/Sunting Manusia Lihat/Sunting Tikus

Sphingosine-1-fosfat reseptor 1 (S1P reseptor 1 atau S1P1), juga dikenal sebagai endotel diferensiasi gen 1 (EDG1) adalah protein yang pada manusia dikodekan oleh gen S1PR1. S1PR1 adalah GReseptor terhubung-protein G yang mengikat sinyal molekul bioaktif sphingosine 1-fosfat (S1P). S1PR1 merupakan anggota subfamili sphingosine-1-fosfat reseptor yang terdiri dari lima anggota (S1PR1-5). S1PR1 awalnya diidentifikasi sebagai transkrip yang melimpah di sel endotel^[4] dan memiliki peran penting dalam mengatur struktur sel endotel sitoskeleton, migrasi, pembentukan jaringan kapiler dan pematangan pembuluh darah.^[5][6] selain itu, sinyal S1PR1 penting dalam regulasi pematangan, migrasi dan penyaluran limfosit,.^[7][8]

Referensi