SLC38A1

Protein-coding gene in the species Homo sapiens
SLC38A1
Identifiers
AliasesSLC38A1, ATA1, NAT2, SAT1, SNAT1, solute carrier family 38 member 1
External IDsOMIM: 608490; MGI: 2145895; HomoloGene: 12745; GeneCards: SLC38A1; OMA:SLC38A1 - orthologs
Gene location (Human)
Chromosome 12 (human)
Chr.Chromosome 12 (human)[1]
Chromosome 12 (human)
Genomic location for SLC38A1
Genomic location for SLC38A1
Band12q13.11Start46,183,063 bp[1]
End46,270,017 bp[1]
Gene location (Mouse)
Chromosome 15 (mouse)
Chr.Chromosome 15 (mouse)[2]
Chromosome 15 (mouse)
Genomic location for SLC38A1
Genomic location for SLC38A1
Band15|15 F1Start96,469,299 bp[2]
End96,540,794 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • lateral nuclear group of thalamus

  • seminal vesicula

  • superficial temporal artery

  • mucosa of sigmoid colon

  • middle temporal gyrus

  • Pars compacta

  • body of tongue

  • Brodmann area 23

  • cerebellar vermis

  • external globus pallidus
Top expressed in
  • deep cerebellar nuclei

  • inferior colliculus

  • retinal pigment epithelium

  • habenula

  • dorsal tegmental nucleus

  • medial vestibular nucleus

  • superior colliculus

  • cerebellar vermis

  • pontine nuclei

  • ventral tegmental area
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • neutral amino acid transmembrane transporter activity
  • protein binding
  • amino acid:sodium symporter activity
  • symporter activity
  • L-amino acid transmembrane transporter activity
  • amino acid transmembrane transporter activity
Cellular component
  • integral component of membrane
  • membrane
  • plasma membrane
  • integral component of plasma membrane
  • extracellular exosome
Biological process
  • sodium ion transport
  • neurotransmitter uptake
  • amino acid transport
  • neutral amino acid transport
  • ion transport
  • L-alpha-amino acid transmembrane transport
  • amino acid transmembrane transport
  • L-amino acid transport
  • transport
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

81539

105727

Ensembl

ENSG00000111371

ENSMUSG00000023169

UniProt

Q9H2H9

Q8K2P7

RefSeq (mRNA)
NM_001077484
NM_001278387
NM_001278388
NM_001278389
NM_001278390

NM_030674

NM_001166456
NM_001166458
NM_134086

RefSeq (protein)
NP_001070952
NP_001265316
NP_001265317
NP_001265318
NP_001265319

NP_109599

NP_001159928
NP_001159930
NP_598847

Location (UCSC)Chr 12: 46.18 – 46.27 MbChr 15: 96.47 – 96.54 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Sodium-coupled neutral amino acid transporter 1 is a protein that in humans is encoded by the SLC38A1 gene.[5][6]

Amino acid transporters play essential roles in the uptake of nutrients, production of energy, chemical metabolism, detoxification, and neurotransmitter cycling. SLC38A1 is an important transporter of glutamine, an intermediate in the detoxification of ammonia and the production of urea. Glutamine serves as a precursor for the synaptic transmitter, glutamate (Gu et al., 2001).[supplied by OMIM][6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000111371 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000023169 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Wang H, Huang W, Sugawara M, Devoe LD, Leibach FH, Prasad PD, Ganapathy V (Sep 2000). "Cloning and functional expression of ATA1, a subtype of amino acid transporter A, from human placenta". Biochem Biophys Res Commun. 273 (3): 1175–9. doi:10.1006/bbrc.2000.3061. PMID 10891391.
  6. ^ a b "Entrez Gene: SLC38A1 solute carrier family 38, member 1".

Further reading

  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
  • Gu S, Roderick HL, Camacho P, Jiang JX (2001). "Characterization of an N-system amino acid transporter expressed in retina and its involvement in glutamine transport". J. Biol. Chem. 276 (26): 24137–44. doi:10.1074/jbc.M009003200. PMID 11325958.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Melone M, Quagliano F, Barbaresi P, et al. (2004). "Localization of the glutamine transporter SNAT1 in rat cerebral cortex and neighboring structures, with a note on its localization in human cortex". Cereb. Cortex. 14 (5): 562–74. doi:10.1093/cercor/bhh018. PMID 15054072.
  • Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.
  • Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
  • Kondoh N, Imazeki N, Arai M, et al. (2007). "Activation of a system A amino acid transporter, ATA1/SLC38A1, in human hepatocellular carcinoma and preneoplastic liver tissues". Int. J. Oncol. 31 (1): 81–7. doi:10.3892/ijo.31.1.81. PMID 17549407.


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