MLF1

Protein-coding gene in the species Homo sapiens
MLF1
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

3UAL, 3UBW

Identifiers
AliasesMLF1, myeloid leukemia factor 1
External IDsOMIM: 601402; MGI: 1341819; HomoloGene: 7839; GeneCards: MLF1; OMA:MLF1 - orthologs
Gene location (Human)
Chromosome 3 (human)
Chr.Chromosome 3 (human)[1]
Chromosome 3 (human)
Genomic location for MLF1
Genomic location for MLF1
Band3q25.32Start158,571,163 bp[1]
End158,607,252 bp[1]
Gene location (Mouse)
Chromosome 3 (mouse)
Chr.Chromosome 3 (mouse)[2]
Chromosome 3 (mouse)
Genomic location for MLF1
Genomic location for MLF1
Band3 E1|3 30.91 cMStart67,281,430 bp[2]
End67,307,336 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • left testis

  • sperm

  • right testis

  • bronchial epithelial cell

  • myocardium

  • cardiac muscle tissue of right atrium

  • right ventricle

  • right auricle

  • biceps brachii

  • Skeletal muscle tissue of biceps brachii
Top expressed in
  • spermatid

  • triceps brachii muscle

  • sternocleidomastoid muscle

  • temporal muscle

  • seminiferous tubule

  • spermatocyte

  • digastric muscle

  • intercostal muscle

  • masseter muscle

  • quadriceps femoris muscle
More reference expression data
BioGPS


More reference expression data
Gene ontology
Molecular function
  • protein binding
  • protein domain specific binding
  • DNA binding
Cellular component
  • nucleus
  • cytoplasm
  • cytoskeleton
  • cilium
  • ciliary basal body
  • cell projection
Biological process
  • multicellular organism development
  • cell cycle
  • cell differentiation
  • myeloid progenitor cell differentiation
  • transcription, DNA-templated
  • regulation of transcription, DNA-templated
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

4291

17349

Ensembl

ENSG00000178053

ENSMUSG00000048416

UniProt

P58340

Q9QWV4

RefSeq (mRNA)
NM_001130156
NM_001130157
NM_001195432
NM_001195433
NM_001195434

NM_022443
NM_001369781
NM_001369782
NM_001369783
NM_001369784
NM_001369785

NM_001039543
NM_010801

RefSeq (protein)
NP_001123628
NP_001123629
NP_001182361
NP_001182362
NP_001182363

NP_071888
NP_001356710
NP_001356711
NP_001356712
NP_001356713
NP_001356714
NP_001365774
NP_001365775
NP_001365776
NP_001365777
NP_001365779
NP_001365780
NP_001365781
NP_001365782
NP_001365784

NP_001034632
NP_034931

Location (UCSC)Chr 3: 158.57 – 158.61 MbChr 3: 67.28 – 67.31 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Myeloid leukemia factor 1 is a protein that in humans is encoded by the MLF1 gene.[5][6]


References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000178053 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000048416 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Yoneda-Kato N, Look AT, Kirstein MN, Valentine MB, Raimondi SC, Cohen KJ, Carroll AJ, Morris SW (Mar 1996). "The t(3;5)(q25.1;q34) of myelodysplastic syndrome and acute myeloid leukemia produces a novel fusion gene, NPM-MLF1". Oncogene. 12 (2): 265–75. PMID 8570204.
  6. ^ "Entrez Gene: MLF1 myeloid leukemia factor 1".

Further reading

  • Lim R, Winteringham LN, Williams JH, et al. (2002). "MADM, a novel adaptor protein that mediates phosphorylation of the 14-3-3 binding site of myeloid leukemia factor 1" (PDF). J. Biol. Chem. 277 (43): 40997–1008. doi:10.1074/jbc.M206041200. PMID 12176995. S2CID 40077371.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Arber DA, Chang KL, Lyda MH, et al. (2003). "Detection of NPM/MLF1 fusion in t(3;5)-positive acute myeloid leukemia and myelodysplasia". Hum. Pathol. 34 (8): 809–13. doi:10.1016/S0046-8177(03)00251-X. PMID 14506644.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Hanissian SH, Akbar U, Teng B, et al. (2004). "cDNA cloning and characterization of a novel gene encoding the MLF1-interacting protein MLF1IP". Oncogene. 23 (20): 3700–7. doi:10.1038/sj.onc.1207448. PMID 15116101.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Yoneda-Kato N, Tomoda K, Umehara M, et al. (2005). "Myeloid leukemia factor 1 regulates p53 by suppressing COP1 via COP9 signalosome subunit 3". EMBO J. 24 (9): 1739–49. doi:10.1038/sj.emboj.7600656. PMC 1142586. PMID 15861129.
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
  • Yoneda-Kato N, Kato JY (2008). "Shuttling imbalance of MLF1 results in p53 instability and increases susceptibility to oncogenic transformation". Mol. Cell. Biol. 28 (1): 422–34. doi:10.1128/MCB.02335-06. PMC 2223285. PMID 17967869.


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