EFCAB6

Protein-coding gene in the species Homo sapiens
EFCAB6
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

1WLZ, 5D67

Identifiers
AliasesEFCAB6, DJBP, HSCBCIP1, dJ185D5.1, EF-hand calcium binding domain 6
External IDsMGI: 1924877; HomoloGene: 11259; GeneCards: EFCAB6; OMA:EFCAB6 - orthologs
Gene location (Human)
Chromosome 22 (human)
Chr.Chromosome 22 (human)[1]
Chromosome 22 (human)
Genomic location for EFCAB6
Genomic location for EFCAB6
Band22q13.2-q13.31Start43,528,744 bp[1]
End43,812,337 bp[1]
Gene location (Mouse)
Chromosome 15 (mouse)
Chr.Chromosome 15 (mouse)[2]
Chromosome 15 (mouse)
Genomic location for EFCAB6
Genomic location for EFCAB6
Band15|15 E1- E2Start83,750,913 bp[2]
End83,949,580 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • left testis

  • right testis

  • sperm

  • buccal mucosa cell

  • right uterine tube

  • bronchial epithelial cell

  • oocyte

  • testicle

  • olfactory zone of nasal mucosa

  • gonad
Top expressed in
  • spermatid

  • seminiferous tubule

  • spermatocyte

  • zygote

  • primary oocyte

  • secondary oocyte

  • muscle of thigh

  • temporal muscle

  • cornea

  • skeletal muscle tissue
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • metal ion binding
  • calcium ion binding
Cellular component
  • nucleus
  • nucleoplasm
Biological process
  • regulation of transcription, DNA-templated
  • transcription, DNA-templated
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

64800

77627

Ensembl

ENSG00000186976

ENSMUSG00000022441

UniProt

Q5THR3

Q6P1E8

RefSeq (mRNA)

NM_022785
NM_198856

NM_001161628
NM_001161629
NM_029946

RefSeq (protein)

NP_073622
NP_942153

NP_001155100
NP_001155101
NP_084222

Location (UCSC)Chr 22: 43.53 – 43.81 MbChr 15: 83.75 – 83.95 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

EF-hand calcium-binding domain-containing protein 6 is a protein that in humans is encoded by the EFCAB6 gene.[5][6][7]


Interactions

EFCAB6 has been shown to interact with PARK7[6] and Androgen receptor.[6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000186976 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000022441 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Hirosawa M, Nagase T, Murahashi Y, Kikuno R, Ohara O (Mar 2001). "Identification of novel transcribed sequences on human chromosome 22 by expressed sequence tag mapping". DNA Res. 8 (1): 1–9. doi:10.1093/dnares/8.1.1. PMID 11258795.
  6. ^ a b c Niki T, Takahashi-Niki K, Taira T, Iguchi-Ariga SM, Ariga H (Mar 2003). "DJBP: a novel DJ-1-binding protein, negatively regulates the androgen receptor by recruiting histone deacetylase complex, and DJ-1 antagonizes this inhibition by abrogation of this complex". Mol Cancer Res. 1 (4): 247–61. PMID 12612053.
  7. ^ "Entrez Gene: FLJ23588 CAP-binding protein complex interacting protein 1".

Further reading

  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
  • Dunham I, Shimizu N, Roe BA, et al. (1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–95. Bibcode:1999Natur.402..489D. doi:10.1038/990031. PMID 10591208.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Collins JE, Goward ME, Cole CG, et al. (2003). "Reevaluating human gene annotation: a second-generation analysis of chromosome 22". Genome Res. 13 (1): 27–36. doi:10.1101/gr.695703. PMC 430954. PMID 12529303.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
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  • 1wlz: Crystal structure of DJBP fragment which was obtained by limited proteolysis
    1wlz: Crystal structure of DJBP fragment which was obtained by limited proteolysis


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