ADAMTSL4

Protein-coding gene in the species Homo sapiens
ADAMTSL4
Identifiers
AliasesADAMTSL4, ADAMTSL-4, ECTOL2, TSRC1, ADAMTS like 4
External IDsOMIM: 610113; MGI: 2389008; HomoloGene: 23141; GeneCards: ADAMTSL4; OMA:ADAMTSL4 - orthologs
Gene location (Human)
Chromosome 1 (human)
Chr.Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for ADAMTSL4
Genomic location for ADAMTSL4
Band1q21.2Start150,549,369 bp[1]
End150,560,937 bp[1]
Gene location (Mouse)
Chromosome 3 (mouse)
Chr.Chromosome 3 (mouse)[2]
Chromosome 3 (mouse)
Genomic location for ADAMTSL4
Genomic location for ADAMTSL4
Band3|3 F2.1Start95,583,511 bp[2]
End95,595,228 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • decidua

  • gastric mucosa

  • tibial nerve

  • left uterine tube

  • muscle of thigh

  • apex of heart

  • upper lobe of left lung

  • canal of the cervix

  • Descending thoracic aorta

  • body of uterus
Top expressed in
  • interventricular septum

  • extraocular muscle

  • muscle of thigh

  • lip

  • myocardium of ventricle

  • ankle

  • sciatic nerve

  • right ventricle

  • temporal muscle

  • cardiac muscles
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • protease binding
  • peptidase activity
  • protein binding
Cellular component
  • extracellular region
  • interstitial matrix
  • endoplasmic reticulum lumen
  • cellular component
  • extracellular matrix
  • collagen-containing extracellular matrix
Biological process
  • positive regulation of apoptotic process
  • extracellular matrix organization
  • proteolysis
  • apoptotic process
  • epithelial cell development
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

54507

229595

Ensembl

ENSG00000143382

ENSMUSG00000015850

UniProt

Q6UY14

Q80T21

RefSeq (mRNA)

NM_001288607
NM_001288608
NM_019032
NM_025008
NM_001378596

NM_001301705
NM_144899

RefSeq (protein)

NP_001275536
NP_001275537
NP_061905
NP_079284
NP_001365525

NP_001288634
NP_659148

Location (UCSC)Chr 1: 150.55 – 150.56 MbChr 3: 95.58 – 95.6 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

ADAMTS-like protein 4 is a protein that in humans is encoded by the ADAMTSL4 gene.[5][6]

Function

This gene is a member of ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs)-like gene family and encodes a protein with seven thrombospondin type 1 repeats. The thrombospondin type 1 repeat domain is found in many proteins with diverse biological functions including cellular adhesion, angiogenesis, and patterning of the developing nervous system. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.[6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000143382 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000015850 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Buchner DA, Meisler MH (Mar 2003). "TSRC1, a widely expressed gene containing seven thrombospondin type I repeats". Gene. 307: 23–30. doi:10.1016/S0378-1119(03)00423-2. PMID 12706885.
  6. ^ a b "Entrez Gene: ADAMTSL4 ADAMTS-like 4".

Further reading

  • Adams JC, Tucker RP (Jun 2000). "The thrombospondin type 1 repeat (TSR) superfamily: diverse proteins with related roles in neuronal development". Developmental Dynamics. 218 (2): 280–299. doi:10.1002/(SICI)1097-0177(200006)218:2<280::AID-DVDY4>3.0.CO;2-0. PMID 10842357.
  • Bonaldo MF, Lennon G, Soares MB (Sep 1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Research. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
  • Dias Neto E, Correa RG, Verjovski-Almeida S, Briones MR, Nagai MA, da Silva W, Zago MA, Bordin S, Costa FF, Goldman GH, Carvalho AF, Matsukuma A, Baia GS, Simpson DH, Brunstein A, de Oliveira PS, Bucher P, Jongeneel CV, O'Hare MJ, Soares F, Brentani RR, Reis LF, de Souza SJ, Simpson AJ (Mar 2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags". Proceedings of the National Academy of Sciences of the United States of America. 97 (7): 3491–3496. Bibcode:2000PNAS...97.3491D. doi:10.1073/pnas.97.7.3491. PMC 16267. PMID 10737800.
  • Wan D, Gong Y, Qin W, Zhang P, Li J, Wei L, Zhou X, Li H, Qiu X, Zhong F, He L, Yu J, Yao G, Jiang H, Qian L, Yu Y, Shu H, Chen X, Xu H, Guo M, Pan Z, Chen Y, Ge C, Yang S, Gu J (Nov 2004). "Large-scale cDNA transfection screening for genes related to cancer development and progression". Proceedings of the National Academy of Sciences of the United States of America. 101 (44): 15724–15729. Bibcode:2004PNAS..10115724W. doi:10.1073/pnas.0404089101. PMC 524842. PMID 15498874.
  • Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–1178. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
  • Liu T, Qian WJ, Gritsenko MA, Camp DG, Monroe ME, Moore RJ, Smith RD (2006). "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry". Journal of Proteome Research. 4 (6): 2070–2080. doi:10.1021/pr0502065. PMC 1850943. PMID 16335952.
  • Liu J, Guo Q, Chen B, Yu Y, Lu H, Li YY (Jan 2006). "Cathepsin B and its interacting proteins, bikunin and TSRC1, correlate with TNF-induced apoptosis of ovarian cancer cells OV-90". FEBS Letters. 580 (1): 245–250. doi:10.1016/j.febslet.2005.12.005. PMID 16364318. S2CID 8768006.

External links

  • GeneReviews/NCBI/NIH/UW entry on ADAMTSL4-Related Eye Disorders,Autosomal Recessive Isolated Ectopia Lentis,Ectopia Lentis et Pupillae
  • Human ADAMTSL4 genome location and ADAMTSL4 gene details page in the UCSC Genome Browser.
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